It can be challenging to figure out what constitutes a normal harmful or lethal dose. Even so, the lethal oral dose of codeine in an Grownup is reported being while in the range of 0.
Use an precise measuring device to measure your dose of promethazine/codeine. A residence spoon just isn't an exact measuring device and could cause you to acquire the wrong dose. Inquire your pharmacist to advocate an correct measuring product.
Get rid of expired, undesired, or unused promethazine/codeine at once by using your drugs to a licensed DEA-registered collector or drug acquire back again method.
The combination of promethazine hydrochloride and codeine phosphate is contraindicated in pediatric sufferers lower than six yrs of age, due to the fact The mixture may possibly lead to lethal respiratory despair In this particular age population.
Lifestyle-threatening respiratory despair and Dying have transpired in young children who acquired codeine. Codeine is issue to variability in metabolism based on CYP2D6 genotype (described beneath), which may lead to an elevated exposure to the active metabolite morphine. Centered on put up-internet marketing studies, kids youthful than twelve decades aged look like more at risk of the respiratory depressant effects of codeine, significantly if you will discover hazard aspects for respiratory despair.
are pregnant or plan to be pregnant. Promethazine Hydrochloride and Codeine Phosphate Oral Option can damage your unborn infant. See “What's The key information and facts I really should learn about Promethazine Hydrochloride and Codeine Phosphate Oral Alternative?” are breastfeeding or intend to breastfeed. Codeine passes into your breast milk and could cause significant Unintended effects within your little one together with improved sleepiness, respiration troubles (respiratory depression), and Demise. It's not regarded if promethazine can move into your breast milk.
A monoamine oxidase inhibitor (MAOI) within the earlier two weeks, that's a medication usually utilized for depression or Parkinson’s ailment
The specific mechanism of action of codeine together with other opiates will not be recognized; having said that, codeine is thought to act centrally over the cough center. In extreme doses, codeine will depress respiration.
Sphincter of Oddi Spasm. The sphincter check here of Oddi is really a muscular valve in Your system that controls the stream of bile and digestive juices from your pancreas to the tiny intestine. When this valve spasms, it might feel like acquiring a restricted muscle cramp, resulting in pain and blocking the circulation of those juices, which may result in distress and digestive issues.
In advance of taking this product or service, explain to your doctor or pharmacist If you're allergic to it; or Should you have another allergies. click here This solution could have inactive elements, which often can result in allergic reactions or other challenges. Talk to your pharmacist For additional facts.
Overdose of codeine in Older people has become related with deadly respiratory melancholy, and the usage of codeine in young children youthful more info than get more info twelve many years of age has been involved with fatal respiratory despair when used as proposed [see Warnings and Safeguards (5.
Promethazine HCl and Codeine Phosphate Oral Remedy may possibly trigger significant hypotension like orthostatic hypotension and syncope in ambulatory patients. There exists improved chance in sufferers whose capability to take care of hypertension has previously been compromised by a lowered blood volume or concurrent administration of specific CNS depressant medication (e.
“If you feel that you're addicted or have concerns for somebody who has been utilizing codeine linctus for as well lengthy, you read more may seek guidance about the NHS Site. Assist groups and self-enable teams can also be offered for example Speak with FRANK.”
No evidence of tumorigenicity was noticed in male and woman mice at codeine dietary doses approximately 400 mg/kg/working day (roughly similar to 45 situations the MRHD on the mg/m2 basis).